About ITI
Copyright Information

COPYRIGHT NOTICE
Copyright © 2002-2007 Intra-Cellular Therapies, Inc., 3960 Broadway, NYC, NY 10032. All rights reserved.

TRADEMARKS
Intra-Cellular Therapies, "The Inside Track for CNS Drug Discovery," "IntraPath" and "CNSProfile™" referenced herein are either trademarks or registered trademarks of Intra-Cellular Therapies, Inc.

Any rights not expressly granted herein are reserved.

LINKS TO THIRD PARTY SITES.
The links in this area will let you leave the Intra-Cellular Therapies, Inc. website. The linked sites are not under the control of Intra-Cellular Therapies, Inc., and Intra-Cellular Therapies, Inc., is not responsible for the contents of any linked site or any link contained in a linked site, or any changes or updates to such sites. Intra-Cellular Therapies, Inc. is not responsible for web casting or any other form of transmission received from any linked site. Intra-Cellular Therapies, Inc., is providing the link(s) to you only as a convenience, and the inclusion of any link does not imply endorsement by Intra-Cellular Therapies, Inc. of the site.

On the home page
The home page includes a crystal structure of indirubin-3'-monoxime in complex with CDK5/p25. The inhibitor binds in the ATP-binding pocket of the catalytic subunit, mainly through hydrophobic interaction and two hydrogen bonds with Leu83. Indirubin-3'-monoxime is shown as a ball-and-stick model, and the molecular surface of CDK5/p25 is coloured according to electrostatic potential, with blue and red representing positive and negative potential, respectively. The figure was created with GRASP program (Nicholls et al., 1991. Proteins 11, 281-296). For details on CDK5/p25 crystal structure see Tarricone, C. et al. (2001) Structure and regulation of the CDK5-p25nck5a complex. Molecular Cell 8, 657-669. (Courtesy of Claudia Crovace, Aldo Tarricone, and Andrea Musacchio, unpublished). Indirubin-3'-monoxime was synthesized by Dr. Leandros Skaltsounis.

Nerve cell images on website kindly provided by Dennis Kunkel, Microscopy, Inc., © Copyright 2001.