Limited treatment options available

 

Bipolar depression is a serious psychiatric clinical presentation of a major depressive episode in a patient who has had at least one prior manic (bipolar I) or hypomanic episode (bipolar II). Bipolar depression is the most common clinical presentation of bipolar disorder and is associated with a worse prognosis than the manic/hypomanic presentation. Bipolar disorder affects approximately 5.7 million adult Americans Bipolar disorder affects approximately 5.7 million adult Americans, or about 2.6% of the US population age 18 and older, every year according to the National Institute of Mental Health. Bipolar depression, the predominant presentation of bipolar disorder, remains a significantly underserved medical need, with only a few FDA-approved treatment options available.