Technology & Products
ITI-002

ITI-002 refers to a novel family of compounds that are potent inhibitors aimed at potentiating the dopamine signal in dopamine target neurons. The target enzyme regulated by ITI-002 is part of the D1 dopamine receptor signaling pathway, which plays a critical role in working memory processes that are involved in maintaining and manipulating information in the mind. These processes guide higher-level behavior and high-level cognition, such as language, problem solving and reasoning.

Preclinical data showed these compounds demonstrate activity, which may be used to treat disorders, such as the cognitive dysfunction in schizophrenia and attention deficit hyperactivity disorder and the cognitive deficits arising from Parkinson¹s and Alzheimer¹s Diseases. ITI-002 also may be useful in treating the motor deficits arising in Parkinson¹s disease.