Major depressive disorder (MDD) is a mood disorder that is one of the most common mental illnesses and affects an estimated 21 million adults in the United States. It can be associated with symptoms of sadness, hopelessness, helplessness, feelings of guilt, irritability, loss of interest in formerly pleasurable activities, cognitive impairment, disturbed sleep patterns and suicidal ideation and behavior.
MDD remains a large unmet medical need.
MDD remains a large unmet medical need as many people do not receive adequate treatment. Only one-third of treated patients adequately respond to first line therapy.